In your opinion, what were the three most important impacts of European exploration/exploitation/colonization on California’s indigenous peoples?

Reading: Chapters 2, 3, 4,5, 6 (no 1)
Question:  In your opinion, what were the three most important impacts of European exploration/exploitation/colonization on California’s indigenous peoples? Make sure you include an explanation of why you came up with your answers.
Write three paragraphs with specific topics and exact details in your discussion. (250-350 words).
(Remember, three paragraphs, one topic per paragraph).